As part of their relationship with the Community Foundation, Chapin, Sumter, Orangeburg and Calhoun have established endowments specific to their areas to better serve local community needs.  

The Greater Chapin Community Endowment, Orangeburg Calhoun Community Foundation and Sumter Community Foundation are each comprised of a local board of advisors that provide leadership over the resources for the nonprofit organizations in their targeted areas. Both enable its citizens ― neighbors, family and friends ― to provide for each other and their futures together as a community.

In addition to these regional affiliate organizations, the Foundation has two supporting organizations. These endowments focus support on specific areas of interest and each operates with its own grantmaking criteria.
 
New Morning Foundation is a non-partisan private-sector long-term initiative to improve young people's reproductive health education, counseling and clinical services throughout South Carolina.

Columbia Jewish Foundation was established to help maintain and support a Jewish community center in the Columbia area that provides social services and recreational programs for use by older adults and the general community. These funds support the Jewish Community Center.